Protein Details: Aquaporin-2
Protein ID
ICDB_Pro_0237
Protein Name
Aquaporin-2
Gene Name
AQP2
Organism
Ovis aries (Sheep)
Length
271 amino acids
AlphaFoldDB
AF-O62735-F1-model_v4.pdb
Function
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient.
Sequence
MWELRSIAFSRAVLAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLAIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAVFYVAAQLLGAVAGAALLHEITPPAIRGDLAVNALNNNSTAGQAVTVELFLTLQLVLCIFPSTDKRRGKQLGHPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAIVTGKFDDHWVFWIGPLVGAIVASLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in renal collecting tubules
DOI ID
10.1007/s004670050627